Will it be possible to generate kidney tissue from induced pluripotent stem cells for regenerative therapy?
نویسندگان
چکیده
منابع مشابه
Induced pluripotent stem cells from human kidney.
Kidney disease is a growing health issue for modern society,1–3 and there are a number of causes, including prematurity, genetic abnormalities, inflammation, hypertension, and diabetes. Current treatments for ESRD include dialysis and transplantation, but both are expensive, rely on continuous intervention, and are imperfect in their application.4 – 6 Transplantation also suffers from lack of a...
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Generation of induced pluripotent stem cells (iPSCs) opens a new avenue in regenerative medicine. One of the major hurdles for therapeutic applications is to improve the efficiency of generating iPSCs and also to avoid the tumorigenicity, which requires searching for new reprogramming recipes. We present a systems biology approach to efficiently evaluate a large number of possible recipes and f...
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Based on cloning studies in mammals, all adult human cells theoretically contain DNA that is capable of creating a whole new person. Cells are maintained in their differentiated state by selectively activating some genes and silencing. The dogma until recently was that cell differentiation was largely fixed unless exposed to the environment of an activated oocyte. However, it is now possible to...
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Regenerative capacity of mammals is limited and can rarely regenerate a specific organ or tissue fully. Due to these limitations, regenerative medicine seeks efficient and safe cell sources for regeneration of damaged tissues and organs or treatment for incurable diseases. Human embryonic stem cells (HESCs) hold two important properties called self renewal and pluripotency. However, the use of ...
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Pluripotent stem cells (PSCs) have gained interest for cell-based regenerative therapies because of their capacity to differentiate into most somatic cell types, including cardiomyocytes. Remarkable progress in the generation of PSC-derived cardiomyocytes has been made in this decade, and recent preclinical transplantation studies using various animal models have provided proof-of-principle for...
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ژورنال
عنوان ژورنال: Regenerative Medicine
سال: 2014
ISSN: 1746-0751,1746-076X
DOI: 10.2217/rme.13.84